The physiological activity of GABA

1950. Florey and Robert's team first discovered GABA in mammalian brain extracts. Nowadays, medical scientists have proved that GABA is an inhibitory substance in the central nervous system. It is the most important neurotransmitter in the brain. Its effect is to reduce neuronal activity and prevent nerve cells from overheating (overfiring). GABA binds to and activates anxiolytic brain receptors and then acts synergistically with other substances. Prevents anxiety-related information from reaching the brain's indicating centers. Therefore, GABA can fundamentally calm the nerves, so as to achieve the effect of anti-anxiety.

In addition, GABA also has the effect of lowering blood pressure, and its main mechanism is to regulate the central nervous system to achieve antihypertensive effect. For example, GABA acts on the vasomotor center of the spinal cord, effectively promoting the expansion of blood vessels and achieving the purpose of lowering blood pressure. It is reported that the effective antihypertensive component of traditional Chinese medicine such as Astragalus is GABA.

1997. The research of Sakutaro Makoto shows that GABA is related to the formation of certain diseases. Parkinson's patients have lower concentrations of GABA in the spinal cord. The GABA concentration in the spinal fluid of epileptic patients was also lower than normal. Researchers at Osaka University School of Medicine in Japan conducted medical tests on rice germ foods rich in GABA. The results showed that GABA had a significant ameliorating effect on Kupperman syndrome. In addition, the decrease of GABA in nerve tissue is related to the development of neurasthenia such as Huntington disease and senile dementia.

Researchers in China and Japan also believe that GABA can inhibit the decarboxylation of glutamate. It reacts with alpha-ketoglutaric acid to produce glutamic acid, which lowers blood ammonia. More glutamic acid combined with ammonia to produce urea excreted in vitro, in order to relieve ammonia toxicity, thereby enhancing liver function. Ingestion of GABA can increase the activity of glucose phosphatase, make brain cells active, promote the metabolism of brain tissue and restore brain cell function, and improve nerve function. Medically, GABA causes symptoms of cerebrovascular disorders. Such as hemiplegia, memory disorders, children's mental retardation and mental childish disease has a good effect, and for uremia, sleep disorders and CO poisoning in the treatment of drugs.

The latest research shows that. GABA in addition to lowering blood pressure and other effects. There are also activities such as mental stability, improvement of kidney function and liver function, promotion of long-term memory, promotion of growth hormone secretion, promotion of alcohol metabolism, deodorization and high-efficiency weight loss.